Along with standard four-speed automatic transmission, the 2006 Buick Lucerne comes with two engine options:
If you’re looking for the best fuel economy with the 2006 Lucerne, you’ll want to go with the V6 engine to receive an EPA rating of 17/26/20 mpg for city/highway/combined driving with regular gasoline. But if you prefer the more potent V8 engine, you’ll have to sacrifice your mileage slightly as the numbers dip down to 15/23/18 mpg.